The Diacylglycerol Acyltransferase 1 Inhibitor, Pradigastat, Was Well Tolerated in a 52-Week Clinical Trial in FCS Patients
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The effect of lavender aromatherapy on well-being in hemodialysis patients: A randomized clinical trial
Hemodialysis patients experience debilitation in spite of the improvement of dialysis techniques. Impaired functioning, well-being and quality of life in these patients are of a great concern. The current study is intended to examine the effects of lavender essential oil on well-being in hemodialysis patients. This randomized clinical trial was conducted on thirty hemodialysis patients. In ex...
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BACKGROUND Evolocumab, a monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9), significantly reduced low-density lipoprotein (LDL) cholesterol levels in phase 2 studies. We conducted a phase 3 trial to evaluate the safety and efficacy of 52 weeks of treatment with evolocumab. METHODS We stratified patients with hyperlipidemia according to the risk categories...
متن کاملExpression of tung tree diacylglycerol acyltransferase 1 in E. coli
BACKGROUND Diacylglycerol acyltransferases (DGATs) catalyze the final and rate-limiting step of triacylglycerol (TAG) biosynthesis in eukaryotic organisms. Database search has identified at least 59 DGAT1 sequences from 48 organisms, but the expression of any DGAT1 as a full-length protein in E. coli had not been reported because DGAT1s are integral membrane proteins and difficult to express an...
متن کاملAffecting Diacylglycerol Acyltransferase A'ctivity'
In characterizing the enzymes involved in the formation of very long-chain fatty acids (VLCFAs) i n the Brassicaceae, we have generated a series of mutants of Arabidopsis thaliana that have reduced VLCFA content. Here we report the characterization of a seed lipid mutant, AS1 1, which, in comparison to wild type (WT), has reduced levels of 20:l and 18:l and accumulates 18:3 as the major fatty a...
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ژورنال
عنوان ژورنال: Journal of Clinical Lipidology
سال: 2015
ISSN: 1933-2874
DOI: 10.1016/j.jacl.2015.03.066